Sub-micromolar concentrations of contrast agent have a quantifiable influence on the hyperpolarized lithium-6 relaxation time in vivo
نویسندگان
چکیده
R. B. van Heeswijk, F. Kurdzesau, C. Cudalbu, A. Comment, J. J. van der Klink, G. Navon, and R. Gruetter Center for BioMedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, VD, Switzerland, Laboratory for Physics of Nanostructured Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, VD, Switzerland, Paul Scherrer Institute, Villigen, Switzerland, School of Chemistry, Tel Aviv University, Tel-Aviv, Israel, Departments of Radiology, Universities of Lausanne and Geneva, Switzerland
منابع مشابه
Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents.
Lithium is widely used in psychotherapy. The (6)Li isotope has a long intrinsic longitudinal relaxation time T(1) on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsicall...
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تاریخ انتشار 2008